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In skeletal muscle, augmented NO signaling has been demonstrated to enhance the delivery of nutrients, promote mitochondrial biogenesis, and facilitate glucose uptake, thereby contributing to improved muscle oxygenation and endurance (28)

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inhibiting this pathway can reduce insulin oversecretion and prevent compensatory insulin resistance caused by persistently high insulin levels in -cells (51, 52)

While IGF-1 levels may exhibit minimal diurnal fluctuation, they are influenced by a number of other biological factors including age and pubertal stage, BMI extremes, pregnancy and to a lesser but still significant degree, sex and ethnicity