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Methods Animals All animal studies were performed in compliance with Association for Assessment and Accreditation of Laboratory Animal Care International and under the supervision of the Mayo Clinic Institutional Animal Care and Use Committee

Research preparations require appropriate reconstitution and storage protocols to maintain the stability and biological activity of both peptide components

Given the limited research, its use as an oral or IV skin-lightening agent during pregnancy or lactation cannot be recommended

In addition, tretinoin promotes epidermal turnover and thins the stratum corneum , increasing the skins susceptibility to sunburn and irritation