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This is consistent with previous research showing that caffeine or coffee can improve NASH-related pathological processes, such as lipid deposition, insulin resistance, oxidative stress, and fibrosis ( EGCG was associated with fewer enriched KEGG pathways than caffeine, including inflammation-related pathways (chemokine signaling, cytokine-cytokine receptor interaction, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, NF-B signaling, etc.), metabolism-related pathways (steroid biosynthesis, glycerophospholipid metabolism, fat digestion and absorption, mTOR signaling, insulin secretion, FoxO signaling, etc.), and other NAFLD-associated pathways (bile secretion) (Figure 7D)

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