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2017 Jan;19(1):29-41

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[38] In Xiaflex-treated 9 patients (0.9%), a combination of penile ecchymosis or hematoma, sudden penile detumescence, and/or a penile popping sound or sensation was reported, and in these cases, a diagnosis of corporal rupture could not be excluded

Even with medications and nicotine replacement therapy, it can be very difficult for some people to stop smoking, in part because they may not be ready to stop or may not want to stop right then, said Johannes