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SUMMARY Injectable ALA is not an FDA-approved drug product

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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

This unfavorable physicochemical profile also culminates in non-specific tissue distribution, where high LogP promotes avid binding to biological membranes and plasma proteins