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Decreased blood flow to the legs can lead to calf pain when walking, but the study found that glutathione given intravenously twice a day helped ease patient symptoms

For a broader overview of what patients commonly notice at the start of treatment, our article on common GLP-1 side effects is a helpful companion read

Missing doses or taking them at inconsistent intervals reduces the steady-state drug levels that produce optimal appetite suppression and metabolic effects

[1] [17] Practical strategies for managing common side effects include: Eat smaller, more frequent meals : Rather than three large meals, consume 46 smaller portions throughout the day to avoid overwhelming your slowed digestive system Choose easily digestible foods : Lean proteins, cooked vegetables, and simple carbohydrates are generally better tolerated than high-fat, fried, or heavily spiced foods Stay well-hydrated : Adequate fluid intake helps prevent constipation and may reduce nausea