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Decreased DA neuron activity in VTA is associated with depression-related behaviors ( Changes in levels of various cytokines, which have potential effects on neurotransmitter metabolism, have been widely observed in the thyroid and orbital tissues of GD patients ( Subsequently, the alteration of these cytokines is involved in the disruption of monoamine neurotransmitters, including serotonin (5-HT), dopamine (DA), and norepinephrine (NE) ( As neurotransmitters play a critical role in the function of the central nervous system, the disrupted metabolism of monoamine neurotransmitters can increase the risk of depressive behaviors
Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]
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