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10.1007/s10552-010-9725-0 39 KawanoY.NagataM.KohnoT.IchimiyaA.IwakiriT.OkumuraM.et al (2012)

Dosing typically starts low and is gradually increased over time to help minimize side effects while maximizing effectiveness

Because both participants and investigators knew which treatment was being administered, the trial introduced a degree of bias that does not affect the blinded pivotal trials

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