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Who may benefit from combined HRT and GLP-1 treatment Not everyone wants or benefits from both treatments, but certain situations may make the combination worth exploring with a clinician: People in perimenopause or menopause experiencing stubborn weight changes despite consistent efforts Those already on HRT who want additional support for weight management People experiencing weight changes alongside metabolic concerns to discuss with a clinician Those who haven't responded well to GLP-1 alone and have hormonal factors at play What works for one person may not be appropriate for another

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At first, temozolomide-loaded PLGA nanoparticles have failed to improve cytotoxicity in U87MG cultures (TMZ alone vs TMZ-PLGA NPs) (71)

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