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Only semaglutide (RR 2.4321 [95% CI 1.1013, 5.3710

[3] For weight management: If discontinuing tirzepatide prescribed for obesity, consider: Establishing a structured nutrition and exercise program before stopping Transitioning to alternative weight management medications if appropriate Setting realistic expectations about weight regain Implementing behavioral strategies and support systems Regular weight monitoring and early intervention if significant regain occurs Practical discontinuation steps: If cost or access issues are driving discontinuation, discuss these openly with your healthcare team, as patient assistance programs, alternative formulations, or therapeutic substitutes may be available

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This framing is speculative but scientifically coherent with the known mechanisms