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Kashin-Beck disease Kashin-Beck disease (KBD) is an endemic condition that affects an estimated 2.5 million people in Tibet, northern and central China, North Korea, and southeastern Siberia, a region of Russia (58)

Effectiveness estimation for clinical outcomes of interest The clinical outcomes included the composite CVD, three-point major adverse cardiovascular events (MACE), fatal CVD, all-cause mortality, and hospitalized hypoglycemia

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These are uncommon, but they suggest a need for caution in people with known high hematocrit, clotting disorders or myeloproliferative conditions