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This process can reduce the potency of the nutrients

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ERR agonism is mechanistically distinct in that it amplifies the transcriptional machinery for oxidative metabolism rather than directly uncoupling mitochondria or stimulating adrenergic pathways

Cocaine neurotoxicity and neurological damage stem from several mechanisms, including mitochondrial dysfunction (Cunha-Oliveira et al., 2010), oxidative stress (Poon et al., 2007), neuroinflammation (Correia et al., 2020), excitotoxicity (Moran et al., 2005), and autophagy (Cao et al., 2017)