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Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism

This sensitizing effect suggests that AS-IV may help mitigate cisplatin-induced toxicity by reducing the required dosage of the chemotherapeutic agent, thereby alleviating cardiotoxicity during cisplatin therapy

Category S2: Peptide Hormones, Growth Factors, Related Substances, and Mimetics This is where the case against GHK-Cu becomes even stronger