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Notably, ECM organization and cytoskeletal stability proteins, including LUM and EZR, were downregulated, highlighting diminished structural support within the polyp ECM compared to gallstones

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Likewise, zeta-potential calculated with satisfactory value (19.07 mV) indicated better stabilization of the composite within colloidal suspension (Fig

Pharmacological targeting of IRE1 in anticancer approaches Gaining pharmacological control over IRE1 activities has been the focus of several anticancer drug development strategies, and these can be divided into two main approaches: (i) inhibiting IRE1 activity to impair adaptability of tumor cells to challenging tumor microenvironment and (ii) activating or hyperactivating IRE1 to initiate its RIDD that leads to cell death