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These include oral semaglutide at 25 mg daily (OASIS-4 trial) and orforglipron, a small-molecule GLP-1 receptor agonist, studied in both obesity without diabetes (ATTAIN-1 trial) and type 2 diabetes (ACHIEVE-1 trial)

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Tirzepatide (a GLP-1/GIP dual agonist) and oral GLP-1 formulations activate slightly different receptor pathways and produce different gastrointestinal response patterns in some patients

Neuroscience (2012) 215:4258.10.1016/j.neuroscience.2012.03.065 45 KhorassaniFEMisherAGarrisS