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Peptides are generally challenging to deliver orally or sublingually because they are large molecules that do not easily cross mucous membranes and are susceptible to enzymatic degradation in the mouth and GI tract

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Depletion of puf-8 results in derepression of PAL-1 in germline SPCs and PAL-1-dependent misexpression of HLH-1 in germ cells (Mainpal et al., 2011)