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But whether high-risk patients will heed the call to step up their medication regimens is the elephant in the room, he added

A protocol combining the two could be designed to investigate whether these two processes can be stimulated concurrently for a more dramatic overall effect on muscle tissue density and size in animal models

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This result is supported by a previous animal study that showed a reduction in liver enzymes and insulin resistance associated with increased dapagliflozin dose [39]