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Summary In essence, semaglutide reduces liver glucose production by: Increasing insulin secretion (which suppresses gluconeogenesis), Decreasing glucagon secretion (which otherwise stimulates hepatic glucose production), Enhancing insulin sensitivity (both directly and via weight loss), and Potential central effects on energy and glucose homeostasis

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It was designed as a longer-lasting alternative to liraglutide (Victoza and other brands), offering patients the convenience of weekly injections rather than daily ones

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