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Lean PCOS : the metabolic rationale is weaker, and other approaches are prioritised

Key Highlights from REIMAGINE 13 REIMAGINE 1 (Diet & Exercise Alone) 40 Weeks HbA1c reduction: 1.8% Weight loss: 13.8% Baseline HbA1c: 7.8% REIMAGINE 2 (Metformin SGLT2 Inhibitor) 68 Weeks HbA1c reduction: 1.91% Weight loss: 14.2% Demonstrated superiority over semaglutide 2.4 mg: * HbA1c: 1.91% vs 1.75% * Weight loss: 14.2% vs 10.2% REIMAGINE 3 (Add-on to Basal Insulin) 40 Weeks HbA1c reduction: 2.33% Weight loss: 12.0% Achieved meaningful metabolic improvements despite background insulin therapy

For example, Wegovy is licensed specifically to reduce cardiovascular risk in people with raised BMI something that becomes increasingly relevant during menopause

& Lang, J