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355,356,357 Giredestrant, despite not reaching statistical significance for the primary endpoint of investigator-assessed PFS in the acelERA BC phase 2 study, demonstrated comparable efficacy to the physicians choice of endocrine monotherapy in key subgroups and showed a beneficial trend in the ESR1 -mutant population

Tirzepatide, a dual GLP-1 and GIP receptor agonist, helps regulate appetite and blood sugar by slowing gastric emptyingwhich can lead to nausea, bloating, or acid reflux in the first few weeks of therapy

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Oxidative stress: the role of estrogen and progesterone