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CrossRef Apple polyphenol extract mitigates high-fat diet induced cognitive impairment in C57BL/6 mice via a sex-dependent mechanism Jieyu Ma, Jiaxin Li, Le Wang, Jinlin Ma, Shilin Chen, Wenxue Luan, Xintong Tian, Siyuan Shang, Xinli Li Food Bioscience .2026

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Dosage adjustments are necessary in patients taking potent CYP3A4 inhibitors such as ritonavir, ketoconazole, and itraconazole (see Dosage and Drug Interactions)

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About 1 in 8 US adults say theyre currently taking one of the medicines, according to KFF, a health policy research group

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