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[2] The theoretical basis for transdermal berberine delivery rests on principles of percutaneous absorption, but the practical effectiveness depends on numerous factors including patch formulation, skin characteristics, and importantly, berberine's physicochemical properties

In Trial 1, postmenopausal women (aged 45 years with 12 consecutive months since last spontaneous menstrual bleeding) were included in order to avoid any potential effect on pharmacokinetics of levonorgestrel and ethinylestradiol caused by physiological hormonal fluctuations seen in women of childbearing potential

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