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The intranasal delivery of quercetin-loaded niosomal in situ gel offers direct central nervous system (CNS) access via the olfactory and trigeminal pathways, minimizing systemic side effects (Gastrointestinal Irritation, Hepatotoxicity, Renal Stress) while enhancing bioavailability

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To assess whether the level of ER stress, which is often coupled to mitochondrial dysfunction 34 , may be impacted by colistin treatment and rescued by co-incubation with L-carnitine, a staining against the ER stress marker GRP78/BiP was conducted

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