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A lower layer with a density as high as approx = 1.16 g/ml should still allow non-viable cells to pellet and this higher density may improve the recovery of viable cells

Collectively, these findings suggest that in individuals with a genetic predisposition, the pathophysiology of migraine is characterized by repeated activation and sensitization of trigeminal nerves by meningeal inflammation, influenced by significant brain activity and resulting in structural and functional brain changes (36)

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