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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation

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Additionally, the authors found that silencing of CYP6CM1 , a gene belonging to the cytochrome P450 family, by RNA interference (RNAi) also reduced the ability of the insect to acquire CCYV compared with the control 14

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