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Composite outcome of CKD progression: defined as doubling of serum creatinine during follow up (mean serum creatinine during follow up divided by mean serum creatinine at index date 2) or incident stage 5 CKD during follow up period

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While leg cramps are not typically listed as a primary side effect in clinical trials, they are a frequent topic of conversation among those using GLP-1 medications

doi: 10.1152/japplphysiol.00599.2016