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These factors extend the network of DAMPs signaling beyond the classical receptors and can further modulate immune cell responses in the postoperative period (for example, IL-33 can drive type 2 immunity and might aid in resolution of injury, whereas HMGB1 sustains inflammation and also promotes immunosuppression in late phases) (53)

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It consists of the first 29 amino acids of the naturally occurring GHRH molecule, the shortest sequence that retains full biological activity