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The hypothesis is that by avoiding -arrestin recruitment, a GLP-1 agonist like CT-996 could lead to less receptor desensitization, decreased internalization, and improved long-term efficacy and tolerability

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Subsequently, AIM2 can be delivered in an IFN-I-dependent manner, leading to the upregulation of its downstream proteins, pyrin and ZBP1

Mohammad Zamani, Naseh Pahlavani, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Rasool Ghaffarian-Ensaf, Omid Asbaghi, Farideh Shiraseb, Samira Rastgoo, 10 January 2023 - L-Carnitine and Male Fertility: Is Supplementation Beneficial?