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Receptor binding versus physiological effect Demonstrating that a molecule binds to GLP-1 and GIP receptors in vitro is a necessary but insufficient condition for therapeutic efficacy

n = 68 mice/group)

These results indicate that downregulation of the PPARa pathway reduces FABP1 expression, leading to alterations in GPX4 and ACSL4 levels that contribute to HMC ferroptosis and IgAN pathogenesis [161]

The dual nature of free radicals plays a crucial role in human physiology and pathology