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On the other hand, it was observed that this drug significantly reduces the expression of IL-6 genes compared to placebo

The internal dialogue shifts from "I am pathetic for not getting up" to "My brain is sick right now, and rest is part of healing." This is not making excuses but acknowledging biological reality

Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis and FAO 81 resulting in defective cell metabolism and carcinogenesis 82 directly targeting key enzymes or transcription factors as oncogenes and tumor suppressors 81 as shown in Table 1