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, 18 , 522-555, doi: Lim, J

Most, D., Leiter, C., Blednov, Y

Nutr Metab Cardiovasc Dis 24(8):808814

Notably, ferroptosis is characterized by lipid ROS accumulation (Guo et al., 2022) Therefore, we speculate that ferroptosis of OA chondrocytes may release a large amount of ROS into the blood circulation, increasing the level of serum oxidative stress, thereby disturbing the intestinal homeostasis and further exacerbating the pathological process of OA