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Furthermore, it has been found that modulation of the Nrf2 signalling pathway by triterpenoids compounds results in a significant increase in survival in the SOD1 G93A mouse model of ALS, thereby indicating that activation of Nrf2 has a neuroprotective effect [268]

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In a controlled study by Samsom and colleagues, healthy subjects given pramlintide showed gastric-emptying half-times that lengthened from about 112 minutes on placebo to roughly 169 minutes at 30 g and 177 minutes at 60 g a delay of more than an hour at the higher dose