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Recent evidence demonstrates a progressive reduction in CB1R density and protein expression across cortical regions, indicating a widespread attenuation of endocannabinoid responsiveness in the aging brain (e.g., deep layer VI, medial prefrontal, temporal) (Ginsburg and Hensler, 2022)

We will explore the mechanisms of action for both medications, analyze current research on their combined use, and offer strategies for managing potential side effects, all while emphasizing the importance of personalized, medically supervised care

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Researchers select the right analog for their experimental needs by understanding these aspects