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Therefore, carnitine/acylcarnitine not only play roles in muscle energy metabolism but also participate in the whole-body energy balance and fatigue perception by affecting neuromuscular signaling, underscoring the potential importance of carnitine in exercise physiology, exercise recovery and performance improvement

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This process is dependent on the upregulation of the SNAIL1 protein and the activation of extracellular signal-regulated kinase (ERK) 2 [91], whereas high expression of Sirtuin 6 (SIRT6) increases hypoxia-inducible factor-1 (HIF-1) to regulate the expression of both SNAIL and TWIST

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