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Ten trials 13,14,2632 had sufficient data for the meta-analysis (n=366 treatment, n=359 control), and five trials 15,26,3335 were excluded from quantitative synthesis due to incomplete or non-extractable data

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These alterations motivate the intestine to reduce mucus manufacture (Vaziri et al., 2012), destructive the intestinal epithelium (Hobby et al., 2019), disturbing the integrity of the intestinal barrier (Plata et al., 2019), changing intestinal permeability (Meijers et al., 2018), and permitting the microflora to be transported to the systemic circulation through the blood to act on the kidneys (Shi et al., 2014)

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