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In the high-glucose hypoxia-induced HK-2 and unilateral nephrectomy combined with STZ-induced DKD rat models, Jin-Chan-Yi-Shen Tong-Luo formula (JCYSTL) activated PINK1/Parkin-mediated mitophagy by stabilizing HIF-1 to protect renal tubules from mitochondrial dysfunction and apoptosis, which provided a promising therapy for the treatment of DKD [130]