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However, Mdv1 has not been detected in mammalian cells (Stojanovski et al., 2004), where FIS1 is required to interact with additional outer membrane receptors, including Mff, MID49, and MID51, to facilitate Drp1 polymerization and assembly into a helical or ring structure surrounding the mitochondrial outer membrane, thereby recruiting Drp1 to the division site, which ultimately initiates fission (Takamura et al., 2012)

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Most available research covers short-term use up to several months, with no major safety signals identified