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In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

Indirect export of reducing equivalents from the chloroplast to resupply NADP for C(3) Photosynthesis-growing importance for stromal NAD(H)

It is a cofactor in the metabolism of fatty acids and its derivative acetyl-L-carnitine helps regulate carbohydrate, protein, and fatty acid metabolism and cellular energy production

This triggers a chain reaction when the peroxyl radical takes hydrogen from another fatty acid, producing a new lipid radical and a lipid peroxide, and on in a sequence, a process termed propagation