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How Quickly Should Treatment Be Initiated in First-Line Combination Therapy or Sequential Therapy, and Does This Depend on Any Specific Circumstances

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To explore the reasons for this, the investigators found increased fat accumulation in muscle and liver tissue as assessed by 1H NMR spectroscopy and an approximately 40% reduction in mitochondrial oxidative and phosphorylation activity as assessed by in vivo 13C/31P NMR spectroscopy (118)

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