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Observations of thyroid C-cell tumors in rodent studies have triggered discussions about potential long-term human risks

A study in July 2024 by researchers at Mass Eye and Ear in Boston found that people taking semaglutide for type 2 diabetes or weight loss had a higher risk of developing nonarteritic anterior ischemic optic neuropathy, an eye condition that can cause blindness, than people taking medications other than GLP-1 drugs for diabetes or obesity

Fermentable fiber increases short-chain fatty acid production, which stimulates GLP-1 release from intestinal cells