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Study selection The criteria for including studies in this meta-analysis were as follows: (1) (i) randomized controlled trials (RCTs) comparing different AOMs with placebo, including glucagon-like peptide 1 receptor agonist (GLP-1 RA), dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RAs, GLP-1 and glucagon receptor (GCGR) dual-agonist, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and bimagrumab

The most common is 5mg/mL, available in 0.5 mL vials (2.5 mg total), 1 mL vials (5 mg total), and 2 mL vials (10 mg total)

The compounds have been found in dietary supplements and products marked as "research only", creating exposure risk for athletes who may purchase such products for cognitive benefits without understanding they're consuming prohibited substances with no established safety profile

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