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And you try to help those people with their side effects by doing things like chewing their food more thoroughly, eating smaller meals but more of them, and drinking more water

What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions

2024;14 doi: 10.1111/cob.12622

21,22 Orlistat, combined with lifestyle changes, contributed to a reduction in weight by 5.8 kg compared to 3.3 kg with placebo over 4 years