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Antioxidant Defense Mechanism It is important to note that while free radicals and ROS are normal byproducts of cellular metabolism, their excessive and uncontrolled production can lead to oxidative stress, which can damage cellular components by oxidizing lipids, disrupting protein structure, and causing DNA strand breaks [39], thereby contributing to impaired cellular function, tissue inflammation, and the development or progression of CLD [40]

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Moreover, in mouse brain mitochondria another study showed that OGC and DIC are both expressed in cortical neurons and astrocytes (Wilkins et al., 2013)