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The mechanistic concern voiced by dermatologists is not usually that the compound initiates melanoma from nothing, but that stimulating melanocytes may accelerate progression of pre-existing dysplastic or early-mutated lesions toward malignancy

The tumor-derived tumor necrosis factor (TNF) or other inflammatory factors can induce MET in human neutrophils, leading to transmigration neutrophils across an activated endothelium, and free radical production results in cancer cell killing

doi:10.1111/j.1749-6632.2003.tb03167.x (source) Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB