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The relatively high incidence of GI AEs in the placebo arms was not unexpected and may in part reflect the known underlying increased risk of GI disorders associated with obesity

Compared to bupropion-naltrexone, patients on GLP-1 agonists medication had nine times higher risk of pancreatitis (inflammation of the pancreas), four times higher risk of bowel obstruction (food is prevented from passing through the small intestine) and three times higher risk of stomach paralysis

Oxidative Stress and the Microbiota-Gut-Brain Axis

Individuals with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid using semaglutide