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The integration of metagenomics, metabolomics, and host immunologic and metabolic profilingapproaches that have been increasingly highlighted in human probiotic trials and precision nutrition studies conducted between 2023 and 2025 will be pivotal in understanding the mechanisms that distinguish responders from non-responders and in developing validated predictive biomarkers to inform personalized probiotic selection (581)

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Breed can influence risk factors and typical activity levels, but it doesnt automatically determine whether supplementation is useful