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Orlistat is the active ingredient in two brand-name drugs for weight loss: Xenical is a prescription-only 120 mg pill that you take three times a day with each meal containing fat (during or up to one hour after the meal)

The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo

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In another study funded by Novo Nordisk, participants with obesity and overweight but without diabetes took 50 mg of oral semaglutide