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Strenuous exercise causes disruption to the permeability of the sarcolemma, allowing proteins and enzymes such as CPK and myoglobin into the bloodstream

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In another 2007 meta-analysis of published studies on HCC, quantitative information on coffee consumption from thousands of cases and controlled studies from Europe and Japan (approximately 240,000 thousand people, among them 2,260 diagnosed with HCC) had similar conclusions: They observed a 41% reduction in the risk of HCC among coffee drinkers compared with never-drinkers