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Looking ahead, future research should include a multidisciplinary collaboration across nutrition, medicine, and pharmaceutical sciences

Decreased ADAM17 expression in the lungs of alpha-Klotho reduced mouse

It exerts its effects through binding to the IGF-2 receptor (IGF-2R), influencing cellular growth, differentiation, and metabolism ( While its role in PAH remains unclear, IGF-2 has been implicated in vascular remodeling and right ventricular hypertrophy in other cardiovascular diseases