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Injection technique to ensure subcutaneous delivery: Important safety reminders : Never share pens or needles with others, even if the needle is changed [1] Use each needle only once and dispose of properly in a sharps container Store unused pens in the refrigerator according to label instructions If you miss a dose, follow the specific instructions in your medication's FDA-approved labeling Do not attempt to administer an extra dose if you suspect improper injection Special considerations : Upper arm injections with Wegovy often require assistance from a caregiver

The active forms of endogenous GLP-1 are primarily GLP-1(7-36) amide and, to a lesser extent, GLP-1(7-37)

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Moreover, loss of CNS Gipr expression potentiates the actions of dulaglutide yet abrogates the additional benefit of combining GIPR blockade with GLP-1R agonism